Blar i forfatter "Cui, Guanglin"

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    • Could Mucosal TNF Transcript as a Biomarker Candidate Help Optimize Anti-TNF Biological Therapy in Patients With Ulcerative Colitis? 

      Cui, Guanglin; Florholmen, Jon; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-19)
      Anti-tumor necrosis factor (TNF) biological therapy has generally been accepted as a standard therapeutic option in inflammatory bowel disease (IBD) patient who are refractory to steroids or immunomodulators. However, the primary and secondary nonresponse rates to anti-TNF bioagents in patients with IBD are high. To improve the response rate, anti-TNF bioagents must be offered to the appropriate ...

    • Differential profile of protumor immunological factors between the tumor site and the tumor-free site – predictive potential of IL-8 and COX2 for colorectal cancer and metastasis 

      Cui, Guanglin; Yuan, Aping; Pang, Zhigang; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-05)
      To study the role of host immune surveillance in the initiation and progression of colorectal cancer (CRC), a set of protumor immunological factors was determined by quantitative real-time PCR (q-PCR) between the primary tumor and the adjacent tumor-free site tissues in 63 patients with colorectal neoplasms. Results showed that expression levels of interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-23, and ...

    • Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR 

      Olsen, Trine; Goll, Rasmus; Florholmen, Jon; Cui, Guanglin (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-03)
      Background In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. ...

    • The presentation and regulation of the IL-8 network in the epithelial cancer stem-like cell niche in patients with colorectal cancer 

      Cui, Guanglin; Li, Gui; Pang, Zhigang; Florholmen, Jon; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-07)
      Background: Accumulative evidence suggests that the biological behavior of cancer stem-like cells (CSCs) is regulated by their surrounding niche, in which cytokines function as one of the main mediators for the interaction between CSCs and their microenvironment in the colorectal cancer (CRC).<p> <p>Methods: We characterized the presentation of CSCs and the interleukin (IL)− 8 network in the ...